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KMID : 0378019700130100081
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New Medical Journal
1970 Volume.13 No. 10 p.81 ~ p.84
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Influence of ginseng on the body weight of rats under stress
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Abstract
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A study was planned to see if the ginseng has any influe ce upon the body weight of rats under stress. Three hundred eighty male rats (body weight:180-200 gm) were equally divided into the ginseng and the saline groups. For 11 days the ginseng group received every day 0.5 ml/100 gm body weight of ginseng extract solution (4 mg of ginseng alcohol extract in 1 ml of saline) subcutaneously,
and the saline group received the same amount of physiological saline. On the 5th day af~er the Ist drug administration, each group was further divided into 5 subgroups, 4 of which received surgical stress of left adreralectomy on the same day while one control subgroup was kept without stress. For 3 days beginning from the 9th experimental day on, each of the subgroups which had undergone sargical stress received for 1 hr every day cold (-10C) or heat (+35C) stress, or 0. 1 unit of ACTH intraperitoneally, except one subgroup that received no further stress. The body weight of all animals was measured on the lst experimental day (before drug administration), on the 5th day (before surgery), on the 8th day (the day before further stress), and on the 11th day after final administration of drug and stress.
Results obtained were as follows:
1. Ginseng significantly facilitated gain in body weight of normal rats without stress.
2. Ginseng tended to suppress loss in body weight of rats under surgical stress, and helped recover the body weight after stress.
3. Rats receiving repeated cold or heat stress or ACTH administration in addition to the previous surgical stress showed a rate of decrease in body weight as conspicuous under the influence of ginseng as under saline, but the absolute value of the body weight was maintained heavier under the ginseng.
It was inferred from the above results that the ginseng facilitates gain in body weight in normal rats and that it tends to suppress loss in and promote restoration of the body weight during and after stress, respectively.
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